BMS-303141

Overview
Catalog #	bs-82230c-5-mg
Product Name	BMS-303141
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Potent and selective ATP citrate lyase (ACL) inhibitor, IC50=0.13 M. Inhibits lipid biosynthesis, IC50=8 M in HepG2 cells.1,2 Reduces weight gain, lowers plasma cholesterol, triglycerides and glucose in high-fat-fed mice.2 A novel tool compound for exploring the potential of ACL inhibition as a target for metabolic disorders such as obesity and dyslipidemia.2 Impairs proliferation or induces death in androgen-depleted castration resistant prostate cancer cells.3 Reduces cell cycle progression in iBN cells.4
Description	CAS Number: 943962-47-8 Chemical Name: 3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1’-biphenyl]-3-yl)-benzenesulfonamide Molecular weight: 424.30 Formula: C19H15Cl2NO4S Solubility: DMSO (25 mg/ml) Ethanol (20 mg/ml) Physical Properties: White solid Purity: 98% by TLC NMR (Conforms)