Importazole

Overview
Catalog #	bs-82229c-5-mg
Product Name	Importazole
Specifications
Storage Buffer	White solid
Storage Condition	RT
Target
Product Information	Specifically inhibits importin-β-mediated nuclear import without disrupting transportin-mediated nuclear import or CRM1-mediated nuclear export1. When added to cells during mitosis it impairs the release of an importin- cargo probe and causes defects in spindle assembly. Inhibition of importin-β function is most likely mediated by blocking its interaction with RanGTP. It is an important new tool to probe the function of the importin-/RanGTP pathway2-4. Cell permeable
Description	CAS Number: 662163-81-7 Chemical Name: N-(1-Phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-amine Molecular weight: 318.43 Formula: C20H22N4 Solubility: DMSO (10 mg/ml) Physical Properties: Off-white solid Purity: 97% by TLC, NMR (Conforms)