SMI-4a

Overview
Catalog #	bs-82198c-5-mg
Product Name	SMI-4a
Specifications
Storage Buffer	Tan solid
Storage Condition	-20°C
Target
Product Information	A selective, ATP-competitive inhibitor of the Pim protein kinases (IC50 = 24 and 100 nM for Pim-1 and Pim-2 respectively). Selective over a panel of ~50 other kinases1. Induces cell cycle arrest in leukemia and prostate cancer cells2. Blocks the growth of a wide range of myeloid and lymphoid cell lines with precursor T-cell lymphoblastic leukemia/lymphoma (pre-T-LBL/T-ALL) being highly sensitive3. A useful tool for exploring the involvement of Pim in cellular signaling4. Cell permeable.
Description	CAS Number: 438190-29-5 Chemical Name: 5-(3-Trifluoromethylbenzylidene)thiazolidine Molecular weight: 273.23 Formula: C11H6F3NO2S Solubility: DMSO (100 mg/ml) Ethanol (40 mg/ml) Physical Properties: Tan solid Purity: 98% by TLC, NMR (conforms)