ML241
| Overview | |
| Catalog # | bs-80333C |
| Product Name | ML241 |
| Specifications | |
| Storage Buffer | powder |
| Storage Condition | -20°C |
| Target | |
| Product Information | Molecular Weight:372.46 Formula:C23H24N4O Purity:>98% Solubility:Soluble in DMSO (up to 50 mg/ml) or Ethanol (up to 14 mg/ml with warming) Chemical Name:N-Benzyl-2-(2,3-dihydro-1,4-benzoxazin-4-yl)-5,6,7,8-tetrahydroquinazolin-4-amine |
| Description | Potent and selective p97 AAA ATPase inhibitor, IC50=100 nM. Inhibits degradation of a p97-dependent but not p97-independent proteasome substrate in a dual-reporter cell line1. It impairs the endoplasmic reticulum-associated degradation (ERAD) pathway.1 ML241 and related inhibitors (DBeQ for example) have differential responses to p97 mutants as well as the presence of cofactors suggesting the possibility of context-dependent p97 inhibitors.2,3 |
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