Fascaplysin

Overview
Catalog #	bs-80312C
Product Name	Fascaplysin
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:306.75 Formula:C18H11ClN2O4 Purity:>98% Solubility:Soluble in DMSO (up to 20 mg/ml) or in Water (up to 2 mg/ml) Chemical Name:12,13-Dihydro-13-oxopyrido[1,2-a:3,4-b’]diindol-5-ium chloride
Description	A novel marine natural product isolated from Thorectandra sp1. A potent and selective inhibitor of cyclin dependent kinase 4/cyclin D1 (IC50 = 0.35 μM) and is less selective for Cdk6/D1 (IC50 = 3.4 μM). Displays antiangiogenic acitivity2. Displays high cytotoxic activity against small cell lung cancer cell lines acting via multiple mechanisms including topoisomerase I, DNA integrity and ROS3.