Indirubin-3'-monoxime
| Overview | |
| Catalog # | bs-80292C |
| Product Name | Indirubin-3'-monoxime |
| Specifications | |
| Storage Buffer | powder |
| Storage Condition | -20°C |
| Target | |
| Product Information | Molecular Weight:277.29 Formula:C16H11N3O2 Purity:>98% Solubility:Soluble in DMSO (up to 6 mg/ml) or in Ethanol (up to 4 mg/ml). Chemical Name:3-[1,3-Dihydro-3-(hydroxyimino-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one |
| Description | A potent GSK-3β inhibitor (IC50=22 nM)1. Also inhibits CDK1 (IC50=180 nM) and CDK5 (IC50=100 nM)1. Displays antimitotic properties and induces endoreplication following prophase arrest in HBL-100 cells2. Possesses antiangiogenic activity3. Attenuates β-amyloid-associated neuropathology in a mouse model of Alzheimer’s disease4. Cell permeable. |
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