XIB4035

Overview
Catalog #	bs-80290C
Product Name	XIB4035
Specifications
Storage Buffer	powder
Storage Condition	RT
Target
Product Information	Molecular Weight:750.45 Formula:C26H31Cl2N3 · 3(H3PO4) Purity:>98% Solubility:Soluble in DMSO (up to 25 mg/ml with warming). Chemical Name:(E)-N4-(7-chloro-2-(2-chlorostyryl)quinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine, 3(H3PO4)
Description	A novel small molecule thought to be an agonist at the glial cell line-derived neurotrophic factor (GDNF) family receptor α-1 GFRα-1. It inhibits radiolabeled GDNF binding in Neuro-2A cells in a concentration dependent manner IC50=10.4 μM. Like GDNF, it induced Ret autophosphorylation and promoted neurite outgrowth in Neuro-2A cells1. Recent studies indicate that it enhances GFRα family receptor signaling in conjunction with ligand stimulation. Effective treatment for small-fiber neuropathy in mouse models of the disease.2,3 GDNF agonists may be a new class of Parkinson’s disease therapeutics.4