NSC405020

Overview
Catalog #	bs-80273C
Product Name	NSC405020
Specifications
Storage Buffer	powder
Storage Condition	RT
Target
Product Information	Molecular Weight:260.15 Formula:C12H15NCl2O Purity:>98% Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). Chemical Name:3,4-Dichloro-N-(1-methylbutyl)benzamide
Description	Membrane type-1 matrix metalloproteinase (MMP14 or MT1-MMP) inhibitor that prevents homodimerization and inhibits MMP14’s protumorigenic activity in vivo. (IC50 > 100 μM). Inhibition is via interaction with the hemopexin domain (PEX) of MMP14. NSC-405020 does not interfere with the catalytic activity of MT1-MMP or MMP-2. Suppresses bone erosion in a c-Fos-deficient mouse model.2 Decreases arsenic-mediated invasion of human squamous cell carcinoma HSC5 cells.3