Salirasib (FTS)
| Overview | |
| Catalog # | bs-80272C |
| Product Name | Salirasib (FTS) |
| Specifications | |
| Storage Buffer | powder |
| Storage Condition | RT |
| Target | |
| Product Information | Molecular Weight:358.54 Formula:C22H30O2S Purity:>98% Solubility:Soluble in DMSO (up to 20 mg/ml) oe in Ethanol (up to 20 mg/ml) Chemical Name:trans-Farnesylthiosalicylic acid |
| Description | Salirasib is a synthetic farnesylcysteine mimetic that inhibits ras proteins1,2 via disruption of interactions between the S-Prenyl moiety of Ras and the membrane anchorage domains3. It has been investigated in the treatment of various cancers.4,5 HCC cells pretreated with salirasib were sensitized to TRAIL-induced apoptosis.6 Salirasib has also been shown to inhibit TRPA1 (EC50 = 1.3 µM).7 |
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