6-Thioguanine
Overview | |
Catalog # | bs-80162C |
Product Name | 6-Thioguanine |
Specifications | |
Storage Buffer | powder |
Storage Condition | -20°C |
Target | |
Product Information | Molecular Weight:167.19 Formula:C5H5N5S Purity:>98% Solubility:Soluble in DMF (up to 1.5 mg/ml with warming) Chemical Name:2-Amino-6-mercaptopurine |
Description | After incorporation into DNA, it disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.1 It reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNA methyltransferase (DNMT1).2 Incorporates into DNA and induces double strand breaks which destabilize DNA structure resulting in cytotoxicity.3 Selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance in a xenograft model.4 Anticancer and immunosuppressive activity. |