5-Fluorouracil
Overview | |
Catalog # | bs-80159C |
Product Name | 5-Fluorouracil |
Specifications | |
Storage Buffer | powder |
Storage Condition | -20°C |
Target | |
Product Information | Molecular Weight:130.08 Formula:C4H3FN2O2 Purity:>98% Solubility:Soluble in DMSO (up to 25 mg/ml). Chemical Name:5-Fluoro-1H,3H-pyrimidine-2,4-dione |
Description | 5-Fluorouracil (5-FU) is a clinically useful anticancer agent that acts via irreversible inhibition of thymidylate synthase. The active metabolites of 5-FU are 5-Fluorodeoxyuridylate (5-FdUMP), 5-Fluorodeoxyuridine triphosphate (5-FdUTP) and 5-Fluorouridine triphosphate (5-FUTP). The primary cytotoxic effect of 5-FU is believed to be inhibition of thymidylate synthase by 5-FdUMP. Secondary effects include incorporation of 5-FdUTP into DNA resulting in DNA strand breaks and incorporation of 5-FUTP into RNA causing abnormal RNA processing.1 |