Mirin

Overview
Catalog #	bs-80047C
Product Name	Mirin
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:220.3 Formula:C10H8N2O2S Purity:>98% Solubility:Soluble in DMSO (up to 30 mg/ml). Chemical Name:2-Amino-5-[(4-hydroxyphenyl)methylene]-4(5H)-thiazolone
Description	Mirin is an inhibitor of the Mre11/Rad50/Nbs1 (MRN) complex which functions as a DNA damage sensor and activates ataxia-telangiectasia mutated kinase (ATM), a DNA repair enzyme1. Mirin blocks the 3’ and 5’ exonuclease activity of Mre112. It enhances the killing of glioblastoma cells after treatment with alkylating agents such as lomustine3. A very useful tool for determining the involvement of Mre11 in DNA damage response4,5.