ZM-447439

Overview
Catalog #	bs-80025C
Product Name	ZM-447439
Specifications
Storage Buffer	powder
Storage Condition	RT
Target
Product Information	Molecular Weight:513.59 Formula:C29H31N5O4 Purity:>98% Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml). Chemical Name:N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide
Description	ZM-447439 is a selective ATP-competitive inhibitor of Aurora kinase B1 (IC50 = 50 nM, Aur A IC50 = 1 µM, Aur C IC50 = 250 nM at physiological ATP concentrations2, Ref.1 lists Aur A IC50 = 110nM and Aur B IC50 = 113nM). It did not significantly inhibit a panel of 14 other kinases including mitotic kinases CDK1 and PLK1. It prevents chromosome alignment, spindle checkpoint function and cytokinesis.1,2