BML-277

Overview
Catalog #	bs-80013C
Product Name	BML-277
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:363.81 Formula:C20H14ClN3O2 Purity:>98% Solubility:Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml). Chemical Name:2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide
Description	Potent selective inhibitor of Chk2 (IC50 = 15 nM). BML-277 has been screened against a panel of 35 kinases, and shows less that 25% inhibition of any other kinase at 10 µM, demonstrating the selectivity1. Also displays radioprotective activity, preventing apoptosis in human T-cells that were subjected to ionizing radiation (EC50 = 3.0 – 7.6 µM).