Alternariol

Overview
Catalog #	bs-75789c-1mg
Product Name	Alternariol
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 1 year after receipt when stored at +4°C. After reconstitution protect from light at -20°C.
Target
Product Information	CAS Number: 641-38-3 Molecular formula: C14H10O5 Molecular weight: 258.2 Purity: >98% (HPLC) Appearance: Light brown solid. Solubility: Soluble in DMSO (20mg/ml) or DMF. Slightly soluble in acetone (1mg/ml). InChiKey: CEBXXEKPIIDJHL-UHFFFAOYSA-N SMILES: OC1=CC(C2=C(C)C=C(O)C=C2O3)=C(C(O)=C1)C3=O
Description	Mycotoxin. Phytotoxin. Shows cytotoxic, teratogenic, mutagenic and genotoxic properties by DNA intercalation. Induces several types of DNA damage, including oxidative DNA damage, single-stranded DNA breaks (SSB) and double-strand, through AOH-induced ROS production and interaction with DNA topoisomerase. Inhibits the activity of topoisomerase IIalpha in mammalian cells. Induces cell growth arrest in G2/M phase. GSK-3beta inhibitor (sub-µM IC50 values). Antiviral activity (herpes simplex). Hepatitis C NS3-4A protease inhibitor. Induces cytochrome P450 1A1 expression and apoptosis in mouse hepatoma cells.