Epacadostat

Overview
Catalog #	bs-75532c-5mg
Product Name	Epacadostat
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 1204669-58-8 Molecular formula: C11H13BrFN7O4S Molecular weight: 438.2 Purity: >98% (HPLC) Appearance: White to off-white solid. Solubility: Soluble in DMSO (~30mg/ml). Insoluble in water. InChiKey: FBKMWOJEPMPVTQ-UHFFFAOYSA-N SMILES: O=S(NCCNC1=NON=C1/C(NC2=CC=C(F)C(Br)=C2)=N/O)(N)=O
Description	Potent and selective competitive indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor. Inhibits IDO1 in enzymatic (IC50=72nM) and in cellular tests (IC50=7.1nM), suppresses tryptophan catabolism in vivo and impedes tumor growth. Displays high selectivity over other related enzymes such as IDO2 or tryptophan 2,3-dioxygenase (TDO). Exhibits potent in vitro and in vivo immunomodulating and antineoplastic activities. By inhibiting IDO1 and decreasing kynurenine levels in tumor cells, Epacadostat increases and restores the proliferation and activation of various immune cells, including dendritic cells (DCs), NK cells and T-lymphocytes, as well as interferon (IFN) production and reduces tumor-associated regulatory T cells (Tregs).