2,5-Dimethyl-celecoxib

Overview
Catalog #	bs-75508c-5mg
Product Name	2,5-Dimethyl-celecoxib
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 457639-26-8 Molecular formula: C18H16F3N3O2S Molecular weight: 395.4 Purity: >99% (HPLC) Appearance: White solid. Solubility: Soluble in DMSO, methanol or dichloromethane. InChiKey: NTFOSUUWGCDXEF-UHFFFAOYSA-N SMILES: CC1=CC=C(C)C(=C1)C1=CC(=NN1C1=CC=C(C=C1)S(N)(=O)=O)C(F)(F)F
Description	Close structural analog of the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib, that lacks COX-2 inhibitory function. Anti-proliferative, anti-tumorigenic and anti-angiogenic. Potent apoptosis inducer in many cancer cell lines. Down-regulates the expression of survivin, cyclins, MMPs and inhibits cyclin-dependent kinase activity. Modulates PDK-1, AKT, GSK3beta, p70 S6K, PKA and MAPKAP-K1alpha. Reduces phosphorylation of ERK1/2 but not AKT T-308 or AKT S-473. Increases intracellular free calcium levels and potently triggers the endoplasmatic reticulum stress response (ESR), activating ER stress-associated proteins GRP78/BiP, CHOP/GADD153 and caspase-4.