GYY 4137

Overview
Catalog #	bs-75438c-10mg
Product Name	GYY 4137
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
Target
Product Information	CAS Number: 106740-09-4 Molecular formula: C11H16NO2PS2 . C4H9NO Molecular weight: 288.4 . 87.1 Purity: >95% (NMR) Appearance: White solid. Solubility: Soluble in DMSO or water. InChiKey: YZMHNNLDUWRZFW-UHFFFAOYSA-N SMILES: C1COCC[NH2+]1.COC1=CC=C(C=C1)P([S-])(=S)N1CCOCC1
Description	Water-soluble, slow-releasing hydrogen sulfide (H2S) donor [1]. Exhibits vasodilator and antihypertensive activity [1, 2, 4]. Anti-inflammatory [2, 3]. Inhibits LPS-induced release of proinflammatory mediators (IL-1beta, IL-6, TNF-alpha, nitric oxide (NO) and PGE2) and increases the synthesis of the anti-inflammatory chemokine IL-10 through NF-kappaB, ATF-2 and HSP27 dependent pathways [2, 3]. Causes stomatal opening and reduces nitric oxide accumulation in plants [5]. Oxidative stress-induced cell death inhibitor [6]. Shows novel anti-cancer effects in vitro and in vivo [7]. Anti-thrombotic via p-selectin dependent mechanism [8].