Artesunate

Overview
Catalog #	bs-75235c-100mg
Product Name	Artesunate
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 1 year after receipt when stored at +4°C.
Target
Product Information	CAS Number: 88495-63-0 Molecular formula: C19H28O8 Molecular weight: 384.4 Purity: >98% (HPLC) Appearance: White solid. Solubility: Soluble in DMSO or ethanol. Sparingly soluble in aqueous buffers. InChiKey: FIHJKUPKCHIPAT-AHIGJZGOSA-N SMILES: [H][C@@]12CC[C@@H](C)[C@]3([H])CC[C@]4(C)OO[C@@]13[C@]([H])(O[C@@H](OC(=O)CCC(O)=O)[C@@H]2C)O4
Description	Semi-synthetic derivative of artemisinin. Anti-malaria. Anti-schistosomiasis. Inhibitor of human cytomegalovirus (CMV). Apoptosis inducer. Anti-cancer. Immunosuppressant. Inhibits production of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1) and nitric oxide (NO). Functional ARX inhibitor. Enhancer of GABAA signalling. Targets Gephyrin. Inducer of glucose-6-phosphate dehydrogenase (G6PDH) activity (25fold), the rate limiting enzyme of the pentose phosphate pathway (PPP). Sown to have anti-SARS-CoV-2 activity with an EC50 of 12.98 ± 5.30µM, and beeing potentially useful in the treatment of COVID-19.