K02288

Overview
Catalog #	bs-6906c-10mg-solid
Product Name	K02288
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 352.38 Formula: C20 H20 N2 O4 CAS Number: 1431985-92-0 InChi Key: CJLMANFTWLNAKC-UHFFFAOYSA-N InChi: InChI=1S/C20H20N2O4/c1-24-17-9-13(10-18(25-2)19(17)26-3)16-8-14(11-22-20(16)21)12-5-4-6-15(23)7-12/h4-11,23H,1-3H3,(H2,21,22) Smiles: COC1C(=CC(=CC=1OC)C1C=C(C=NC=1N)C1C=C(O)C=CC=1)OC Purity: 98.0 Solubility: Soluble in DMSO, not in water Appearance: Solid Power. Shelf Life: 1.0 years
Description	K02288 is a potent inhibitor of BMP signaling. K02288 has in vitro activity against ALK2 at low nanomolar concentrations similar to the current lead compound LDN-193189. K02288 specifically inhibited the BMP-induced Smad pathway without affecting TGF-β signaling and induced dorsalization of zebrafish embryos.