LDN-212854

Overview
Catalog #	bs-6905c-10mg-solid
Product Name	LDN-212854
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 406.48 Formula: C25 H22 N6 CAS Number: 1432597-26-6 InChi Key: BBDGBGOVJPEFBT-UHFFFAOYSA-N InChi: InChI=1S/C25H22N6/c1-3-21(22-4-2-10-27-24(22)5-1)23-16-29-31-17-19(15-28-25(23)31)18-6-8-20(9-7-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 Smiles: C1CNCCN1C1C=CC(=CC=1)C1=CN2N=CC(=C2N=C1)C1C=CC=C2N=CC=CC=12 Purity: 98.0 Solubility: DMSO : ≥ 30 mg/mL (73.80 mM) Appearance: Solid Power. Shelf Life: 1.0 years
Description	LDN-212854 is a potent and selective BMP receptor inhibitor with IC50 of 1.3 nM for ALK2. LDN-212854 exhibits some selectivity for ALK2 in preference to other BMP type I receptors, ALK1 and ALK3, which may permit the interrogation of ALK2-mediated signaling, transcriptional activity, and function. LDN-212854 potently inhibits heterotopic ossification in an inducible transgenic mutant ALK2 mouse model of fibrodysplasia ossificans progressiva. The bone morphogenetic protein (BMP) signaling pathway has essential functions in development, homeostasis, and the normal and pathophysiologic remodeling of tissues. Small molecule inhibitors of the BMP receptor kinase family have been useful for probing physiologic functions of BMP signaling in vitro and in vivo and may have roles in the treatment of BMP-mediated diseases.