CC-930

Overview
Catalog #	bs-6544c-2mg-solid
Product Name	CC-930
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 448.44 Formula: C21 H23 F3 N6 O2 CAS Number: 899805-25-5 InChi Key: IBGLGMOPHJQDJB-MOKVOYLWSA-N InChi: InChI=1S/C21H23F3N6O2/c22-11-7-15(23)18(16(24)8-11)28-21-27-17-9-25-20(26-12-1-3-14(31)4-2-12)29-19(17)30(21)13-5-6-32-10-13/h7-9,12-14,31H,1-6,10H2,(H,27,28)(H,25,26,29)/t12?,13-,14?/m0/s1 Smiles: OC1CCC(CC1)NC1N=C2C(=CN=1)N=C(NC1C(F)=CC(F)=CC=1F)N2[C@@H]1COCC1 Purity: 98.0 Solubility: DMSO: 89 mg/mLwarmed(183.54 mM). Water: 4 mg/mLwarmed(8.24 mM). Appearance: Solid Power Shelf Life: 1.0 years
Description	CC-930, also known as Tanzisertib, is a potent, selective, and orally active JNK inhibitor with potential antifibrotic activity. CC-930 entered Phase I clinical trials. Tanzisertib may have potential use for prevention and treatment of dermal fibrosis. Selective inhibition of JNK by CC-930 exerted potent antifibrotic effects in vitro and in different models in vivo. JNK might thus be a novel molecular target for the treatment of fibrosis in SSc.