ML-329

Overview
Catalog #	bs-6543c-2mg-solid
Product Name	ML-329
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 328.34 Formula: C16 H12 N2 O4 S CAS Number: 19992-50-8 InChi Key: CSYFFQVEQXEIAB-UHFFFAOYSA-N InChi: InChI=1S/C16H12N2O4S/c17-23(21,22)11-7-5-10(6-8-11)18-14-9-15(19)12-3-1-2-4-13(12)16(14)20/h1-9,18H,(H2,17,21,22) Smiles: NS(=O)(=O)C1C=CC(=CC=1)NC1=CC(=O)C2=CC=CC=C2C1=O Purity: 98.0 Solubility: DMSO : 5 mg/mL (15.23 mM; Need ultrasonic) DMF : 5 mg/mL (15.23 mM; Need ultrasonic) Appearance: Solid Power Shelf Life: 1.0 years
Description	ML-329 is an inhibitor of the microphthalmia-associated transcription factor (MITF) pathway with an IC50 value of 1.2 μM for promoter activity of the MITF target gene TRPM-1. ML-329 showed specific activity against the MITF-dependent cells, primary melanocytes but no effect on the viability in A375 cells. ML-329 reduced the expression of multiple MITF target genes, including pigment-related genes and the cell cycle regulator CDK2. As a tool compound, ML-329 will be useful in elucidating the role of MITF in melanocyte lineage development and in melanoma disease progression.