PBTZ-169

Overview
Catalog #	bs-6527c-2mg-solid
Product Name	PBTZ-169
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 456.48 Formula: C20 H23 F3 N4 O3 S CAS Number: 1377239-83-2 InChi Key: BJDZBXGJNBMCAV-UHFFFAOYSA-N InChi: InChI=1S/C20H23F3N4O3S/c21-20(22,23)14-10-15-17(16(11-14)27(29)30)31-19(24-18(15)28)26-8-6-25(7-9-26)12-13-4-2-1-3-5-13/h10-11,13H,1-9,12H2 Smiles: [O-][N+](=O)C1=CC(=CC2=C1SC(=NC2=O)N1CCN(CC2CCCCC2)CC1)C(F)(F)F Purity: 98.0 Solubility: DMSO: 5 mg/mL(10.95 mM). Appearance: Solid Power Shelf Life: 1.0 years
Description	PBTZ-169, also known as macozinone, is a new drug candidate that inhibits decaprenyl-phosphoribose-epimerase (DprE1), an essential enzyme involved in the cell wall biosynthesis of Corynebacterineae. The MIC values of PBTZ-169 ranged from 0.03 μg/mL to 0.0037 μg/mL. The MIC50 and MIC90 values of PBTZ-169 were 0.0075 and 0.030 μg/mL, respectively. The MIC for PBTZ-169 for N. brasiliensis HUJEG-1 was 0.0037 μg/mL. The MICs of SXT, DA-7218, and BTZ043 for this strain were 9.5/0.5, 8, and 0.125 μg/mL, respectively.