VU-0357121

Overview
Catalog #	bs-6526c-2mg-solid
Product Name	VU-0357121
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 305.32 Formula: C17 H17 F2 N O2 CAS Number: 433967-28-3 InChi Key: AHCYOTLTLQTPSU-UHFFFAOYSA-N InChi: InChI=1S/C17H17F2NO2/c1-2-3-10-22-14-7-4-12(5-8-14)17(21)20-16-9-6-13(18)11-15(16)19/h4-9,11H,2-3,10H2,1H3,(H,20,21) Smiles: CCCCOC1C=CC(=CC=1)C(=O)NC1C=CC(F)=CC=1F Purity: 98.0 Solubility: DMSO: 61 mg/mL(199.79 mM). Appearance: Solid Power Shelf Life: 1.0 years
Description	VU-0357121 is a positive allosteric modulator of mGlu5 receptors (EC50 = 33 nM). Mutagenesis studies indicate that VU-0357121 and related analogues bind to a yet uncharacterized allosteric site on mGlu(5), distinct from CPPHA, yet share a functional interaction with the MPEP site.