UNBS-5162

Overview
Catalog #	bs-60417c-2-mg-solid
Product Name	UNBS-5162
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 326.35 Formula: C17 H18 N4 O3 CAS Number: 956590-23-1 InChi Key: WCKZRLOUKYFJDY-UHFFFAOYSA-N InChi: InChI=1S/C17H18N4O3/c1-20(2)6-7-21-15(22)12-5-3-4-10-8-11(19-17(18)24)9-13(14(10)12)16(21)23/h3-5,8-9H,6-7H2,1-2H3,(H3,18,19,24) Smiles: CN(C)CCN1C(=O)C2=CC=CC3C=C(C=C(C=32)C1=O)NC(N)=O Purity: 98.0 Solubility: DMSO: 21.5 mg/mL Appearance: Solid Power. Shelf Life: 1.0 years
Description	UNBS5162 is a novel naphthalimide that binds to DNA by intercalation and suppresses CXCL chemokine elaboration. In vivo UNBS5162 after repeat administration significantly increased survival in orthotopic human prostate cancer models. Results obtained by the National Cancer Institute (NCI) using UNBS3157 and UNBS5162 against the NCI 60 cell line panel did not show a correlation with any other compound present in the NCI database, including amonafide, thereby suggesting a unique mechanism of action for these two novel naphthalimides.