AS8351, KDM5B Inhibitor

Overview
Catalog #	bs-60330c-2-mg-solid
Product Name	AS8351, KDM5B Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 291.3 Formula: C17 H13 N3 O2 CAS Number: 796-42-9 InChi Key: WQSHHAVECQJKLX-YBFXNURJSA-N InChi: InChI=1S/C17H13N3O2/c21-16-6-5-12-3-1-2-4-14(12)15(16)11-19-20-17(22)13-7-9-18-10-8-13/h1-11,21H,(H,20,22)/b19-11+ Smiles: OC1C=CC2=CC=CC=C2C=1C=NNC(=O)C1C=CN=CC=1 Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	AS8351 is a potent iron chelator that has been found to inhibit of histone demethylase KDM5B (JARID1B) by competing with a-ketoglutarate. KDM5B a histone H3K4 demethylase involved in regulation of cell proliferation and stem cell self-renewal and differentiation. It can induce reprogramming of human fetal lung fibroblasts into functional cardiomyocytes, in combination with CHIR99021, A83-01, BIX01294, SC1, Y-27632, OAC2, SU16f and JNJ10198409.