ME0328, PARP-3 Inhibitor

Overview
Catalog #	bs-60329c-2-mg-solid
Product Name	ME0328, PARP-3 Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 321.37 Formula: C19 H19 N3 O2 CAS Number: 1445251-22-8 InChi Key: QIHBWVVVRYYYRO-ZDUSSCGKSA-N InChi: InChI=1S/C19H19N3O2/c1-13(14-7-3-2-4-8-14)20-18(23)12-11-17-21-16-10-6-5-9-15(16)19(24)22-17/h2-10,13H,11-12H2,1H3,(H,20,23)(H,21,22,24)/t13-/m0/s1 Smiles: C[C@H](NC(=O)CCC1NC(=O)C2=CC=CC=C2N=1)C1C=CC=CC=1 Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	ME0328 is a potent, selective and cell permeable PARP-3 inhibitor with IC50 of 0.89 μM. It has good selectivity against PARP-1, PARP-2 and other ARDT enzymes. Enhances CRISPR-Cas9-mediated HER2 mutation frequency, resulting in increased reduction in proliferation of HER2-positive breast cancer cells.