NSC636819, KDM4A/KDM4B Inhibitor
| Overview | |
| Catalog # | bs-60290c-2-mg-solid |
| Product Name | NSC636819, KDM4A/KDM4B Inhibitor |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Store in dry, dark place at -20C for 1 year. |
| Target | |
| Product Information | Molecular Weight: 510.15 Formula: C22 H12 Cl4 N2 O4 CAS Number: 1618672-71-1 InChi Key: YYZPXBXVBQSBDG-IJIVKGSJSA-N InChi: InChI=1S/C22H12Cl4N2O4/c23-17-7-3-13(9-19(17)25)1-5-15-11-16(22(28(31)32)12-21(15)27(29)30)6-2-14-4-8-18(24)20(26)10-14/h1-12H/b5-1+,6-2+ Smiles: [O-][N+](=O)C1C=C(C(=CC=1/C=C/C1=CC(Cl)=C(Cl)C=C1)/C=C/C1=CC(Cl)=C(Cl)C=C1)[N+]([O-])=O Purity: 98.0 Solubility: DMSO up to 10 mM Appearance: Solid Power. Shelf Life: 1.0 years |
| Description | NSC636819 is a cell permeable and selective novel active-site KDM4A/KDM4B inhibitor with IC50 ~6.4 μM for KDM4A and 9.3 μM for KDM4B. It inhibits histone demethylase activity on H3K9me3 and induces apoptosis in LNCaP prostate cancer cells in vitro. It also negatively regulates androgen-responsive genes. The overexpression of KDM4A/KDM4B in prostate cancer and their association with androgen receptor suggest that KDM4A/KDM4B are potential progression factors for prostate cancer. |
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