SirReal2, Sirt2 Inhibitor

Overview
Catalog #	bs-60289c-2-mg-solid
Product Name	SirReal2, Sirt2 Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 420.55 Formula: C22 H20 N4 O S2 CAS Number: 709002-46-0 InChi Key: MENNDDDTIIZDDN-UHFFFAOYSA-N InChi: InChI=1S/C22H20N4OS2/c1-14-10-15(2)25-22(24-14)28-13-20(27)26-21-23-12-18(29-21)11-17-8-5-7-16-6-3-4-9-19(16)17/h3-10,12H,11,13H2,1-2H3,(H,23,26,27) Smiles: CC1C=C(C)N=C(N=1)SCC(=O)NC1=NC=C(CC2=CC=CC3=CC=CC=C23)S1 Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	SirReal2 is a potent and selective Sirt2 inhibitor with IC50 ~140 nM, has minimal effect on Sirt1 and Sirt3-6. It occupies the extended C-site and induces a major rearrangement of Sirt2’s active site, so it selectively inhibits Sirt2 and functions as a molecular wedge to lock Sirt2 in an open conformation. SirReal2 can increase tubulin hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1. It could be a useful chemical tool for sirtuin biology.