PFI-4, BRPF1 Bromodomain Inhibitor

Overview
Catalog #	bs-60264c-2-mg-solid
Product Name	PFI-4, BRPF1 Bromodomain Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 380.44 Formula: C21 H24 N4 O3 CAS Number: 900305-37-5 InChi Key: QCIJLRJBZDBVDB-UHFFFAOYSA-N InChi: InChI=1S/C21H24N4O3/c1-23-17-12-15(22-20(26)14-8-4-5-9-19(14)28-3)16(25-10-6-7-11-25)13-18(17)24(2)21(23)27/h4-5,8-9,12-13H,6-7,10-11H2,1-3H3,(H,22,26) Smiles: COC1C=CC=CC=1C(=O)NC1=CC2=C(C=C1N1CCCC1)N(C)C(=O)N2C Purity: 98.0 Solubility: DMSO up to 50 mM, EtOH up to 10 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	PFI-4 is a potent, selective and cell permeable BRPF1 bromodomain inhibitor. It binds to BRPF1B with a Kd of 13 nM (ITC). It has general >100-fold selectivity against other bromodomains including BRPF2, BRPF3 and BRD4. It reduces recovery time in triple BRD cell construct in FRAP and is potent in cells with IC50 250 nM, while showing no effect on BRPF1A.