FG-4592 (Roxadustat), HIF Prolyl-Hydroxylases Inhibitor

Overview
Catalog #	bs-60263c-2-mg-solid
Product Name	FG-4592 (Roxadustat), HIF Prolyl-Hydroxylases Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 352.34 Formula: C19 H16 N2 O5 CAS Number: 808118-40-3 InChi Key: YOZBGTLTNGAVFU-UHFFFAOYSA-N InChi: InChI=1S/C19H16N2O5/c1-11-15-9-13(26-12-5-3-2-4-6-12)7-8-14(15)18(24)17(21-11)19(25)20-10-16(22)23/h2-9,24H,10H2,1H3,(H,20,25)(H,22,23) Smiles: CC1=NC(C(=O)NCC(O)=O)=C(O)C2=CC=C(C=C21)OC1C=CC=CC=1 Purity: 98.0 Solubility: DMSO up to 50 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	FG-4592 (Roxadustat) is a potent, selective and bioavailable inhibitor of hypoxia-inducible factor prolyl hydroxylase. It is an analog of 2-oxoglutarate (2-OG) to inhibit HIF-PH and prevent HIF turnover. While little has been published regarding the actions of this compound, similar HIF-PH inhibitors suppress HIF degradation and in this way induce erythropoietin expression, promoting erythropoiesis or preventing anemia in vivo. Right now FG-4592 is in phase III clinical trials to treat anemia.