CGK733

Overview
Catalog #	bs-1040c-2mg-solid
Product Name	CGK733
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 555.84 Formula: C23 H18 Cl3 F N4 O3 S CAS Number: 905973-89-9 InChi Key: HLCDNLNLQNYZTK-UHFFFAOYSA-N InChi: InChI=1S/C23H18Cl3FN4O3S/c24-23(25,26)21(30-22(35)28-16-11-12-17(27)18(13-16)31(33)34)29-20(32)19(14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-13,19,21H,(H,29,32)(H2,28,30,35) Smiles: [O-][N+](=O)C1C=C(C=CC=1F)NC(=S)NC(NC(=O)C(C1=CC=CC=C1)C1=CC=CC=C1)C(Cl)(Cl)Cl Purity: 98.0 Solubility: 10 mM in DMSO Appearance: Solid Power. Shelf Life: 1.0 years
Description	CGK733 is an ATM inhibitor and ATR inhibitor, which significantly enhanced taxol-induced cytotoxicity in HBV-positive HepG2.2.15 cells. The mechanism lies in CGK733 triggers the formation of multinucleated cells thus promotes the premature mitotic exit of taxol-induced mitotic-damaged cells through multinucleation and mitotic catastrophe in HBV-positive HepG2.2.15 cells. These results suggest that CGK733 could potentially reverse the taxol resistance in HBV-positive HCC cells and may suggest a novel strategy to treat HBV-infected HCC patients.