Syndecan binding protein Monoclonal Antibody + Cell Lysate Kit
Applications
Reactivity
| Overview | |
| Catalog # | bsm-90027R |
| Product Name | Syndecan binding protein Monoclonal Antibody + Cell Lysate Kit |
| Applications | WB, FCM, IC |
| Specificity | Knockdown Validated |
| Reactivity | Human |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Rabbit |
| Source | A synthesized peptide derived from human Syntenin |
| Immunogen Range | 2-79/298 |
| Clonality | Monoclonal |
| Clone # | 23GB2185 |
| Isotype | IgG |
| Concentration | Lot dependent |
| Purification | Affinity Purified |
| Storage Buffer | Supplied in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide. |
| Storage Condition | -20 °C |
| Target | |
| Gene ID | 6386 |
| Swiss Prot | O00560 |
| Synonyms | SDCBP; Syndecan Binding Protein; MDA-9; SYCL; Syntenin-1; Pro-TGF-Alpha Cytoplasmic Domain-Interacting Protein 18; Syndecan-Binding Protein 1; Scaffold Protein Pbp1; TACIP18; SDCBP1; MDA9; Melanoma Differentiation Associated Protein-9; Melanoma Differentiation-Associated Protein 9; Syndecan Binding Protein (Syntenin); Syntenin; ST1 |
| Background | Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway. Cell Line: HeLa Knockdown technology: shRNA Knockdown |
| Application Dilution | |
| WB | : 1:1000-1:5000 |
| FCM | FCM: 1:2000 |
| IC | IC: 1:1000 |
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