NME1 Monoclonal Antibody + Cell Lysate Kit
Applications
Reactivity
| Overview | |
| Catalog # | bsm-90026R |
| Product Name | NME1 Monoclonal Antibody + Cell Lysate Kit |
| Applications | WB, IC |
| Specificity | Knockdown Validated |
| Reactivity | Human |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Rabbit |
| Source | A synthesized peptide derived from human NM23A |
| Immunogen Range | 1-50/152 |
| Clonality | Monoclonal |
| Clone # | 23GB2180 |
| Isotype | IgG |
| Concentration | Lot dependent |
| Purification | Affinity Purified |
| Storage Buffer | Supplied in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide. |
| Storage Condition | -20 °C |
| Target | |
| Gene ID | 4830 |
| Swiss Prot | P15531 |
| Synonyms | NME1; NME/NM23 Nucleoside Diphosphate Kinase 1; NM23-H1; NDPKA; NM23; Non-Metastatic Cells 1, Protein (NM23A) Expressed In; Tumor Metastatic Process-Associated Protein; Metastasis Inhibition Factor Nm23; Nucleoside Diphosphate Kinase A; Granzyme A-Activated DNase; NDP Kinase A; EC 2.7.4.6; GAAD; Epididymis Secretory Sperm Binding Protein; NDPK-A; NDK;NDKA; AWD; NBS; NB |
| Background | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. Cell Line: HeLa Knockdown technology: shRNA Knockdown |
| Application Dilution | |
| WB | : 1:1000-1:5000 |
| IC | IC: 1:1000 |
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