Tax1 binding protein 1 Monoclonal Antibody + Cell Lysate Kit
Applications
Reactivity
Overview | |
Catalog # | bsm-90018R |
Product Name | Tax1 binding protein 1 Monoclonal Antibody + Cell Lysate Kit |
Applications | WB, FCM, IC |
Specificity | Knockdown Validated |
Reactivity | Human, Mouse, Rat |
Specifications | |
Conjugation | Unconjugated |
Host | Rabbit |
Source | A synthesized peptide derived from human TRAF6BP |
Immunogen Range | 720-789/789 |
Clonality | Monoclonal |
Clone # | 23GB2100 |
Isotype | IgG |
Concentration | Lot dependent |
Purification | Affinity Purified |
Storage Buffer | Supplied in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide. |
Storage Condition | -20 °C |
Target | |
Gene ID | 8887 |
Swiss Prot | Q86VP1 |
Synonyms | TAX1BP1; Tax1 Binding Protein 1; CALCOCO3; TXBP151; Tax1 (Human T-Cell Leukemia Virus Type I) Binding Protein 1; Tax1-Binding Protein 1; TRAF6-Binding Protein; T6BP |
Background | Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation. Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates. Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production. Recruits also A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways. Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling. As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis. Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation. Mediates the autophagic degradation of other substrates including TICAM1. Cell Line: HeLa Knockdown technology: shRNA Knockdown |
Application Dilution | |
WB | : 1:1000-1:5000 |
FCM | FCM: 1:2000 |
IC | IC: 1:1000 |