Overview |
bs-2976R-APC-Cy5.5 |
GGT1 Polyclonal Antibody, APC-Cy5.5 Conjugated |
WB, FCM |
Human |
Mouse, Rat |
Specifications |
APC-Cy5.5 |
Rabbit |
KLH conjugated synthetic peptide derived from human GGT1 |
351-460/569 |
Polyclonal |
IgG |
1ug/ul |
Purified by Protein A. |
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
Target |
2678 |
P19440 |
Cell membrane |
GGT; GTG; CD224; GGT 1; D22S672; D22S732; Gamma-glutamyltranspeptidase 1; Gamma-glutamyltransferase 1; Glutathione hydrolase 1; Leukotriene-C4 hydrolase; GGT1 |
Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide, cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Isoform 3 seems to be inactive. |
Application Dilution |
WB |
1:300-5000 |
FCM |
1:20-100 |