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mouse CD45RB/PE

Applications

  • FCM

Reactivity

  • Mouse
Overview
Catalog # bsm-30160A-PE
Product Name mouse CD45RB/PE
Applications FCM
Reactivity Mouse
Specifications
Conjugation Unconjugated
Host Rat
Clonality Monoclonal
Clone # 8C7
Isotype IgG2a/Kappa
Concentration n/a
Purification Affinity purified by Protein G
Storage Buffer 0.01M PBS, 0.5%BSA, 0.03% Proclin300
Storage Condition Store at 2-8℃. Protect from light. Avoid freezing.
Target
Gene ID 19264
Swiss Prot P06800
Background CD45RB is an isoform of CD45 with exon 5 splicing (encodes B determinant). It is a 220 kD glycoprotein expressed on peripheral B cells, naïve T cells, thymocytes, weakly on macrophages, and dendritic cells. It plays a critical role in TCR and BCR signaling. As T cells become activated and progress from naïve to memory cells, CD45RB expression is downregulated. Additionally, functionally distinct CD4+ T cell subsets, which secrete differing cytokine profiles, can be separated by CD45RB intensity. The primary ligands for CD45 are galectin-1, CD2, CD3, CD4 and Thy-1.
Application Dilution
FCM 1:20-100