| Overview |
| bs-0273R-Biotin |
| PBEF (CT) Polyclonal Antibody, Biotin Conjugated |
| IHC-P, IHC-F |
| Human |
| Mouse, Rat, Dog, Cow, Horse, Chicken, Monkey |
| Specifications |
| Biotin |
| Rabbit |
| KLH conjugated synthetic peptide derived from human Nicotinamide phosphoribosyltransferase |
| 401-491/491 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Store at -20°C for 12 months. |
| Target |
| 10135 |
| P43490 |
| Cytoplasm, Nucleus |
| VF; PBEF; PBEF1; VISFATIN; 1110035O14Rik; Nicotinamide phosphoribosyltransferase; NAmPRTase; Nampt; Pre-B-cell colony-enhancing factor 1; Pre-B cell-enhancing factor |
| Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity). |
| Application Dilution |
| IHC-P |
1:200-400 |
| IHC-F |
1:100-500 |
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