| Overview |
| bsm-62336r-bf405-100ul |
| ABI2 Recombinant Antibody, AbBy Fluor® 405 Conjugated |
| WB, IF(ICC) |
| Human, Mouse, Rat |
| Specifications |
| AbBy Fluor® 405 |
| Rabbit |
| KLH conjugated synthetic peptide derived from human ABI2 |
| Recombinant |
| IgG |
| Lot dependent |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 10152 |
| Q9NYB9 |
| Cytoplasm |
| Abelson interactor 2; ABI2; ABI2B; Abl binding protein 3; AblBP3; ArgBP1; ARGBPIA; ArgBPIB; SSH3BP2. |
| Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation.Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge. |
| Application Dilution |
| WB |
1:300-5000 |
| IF(ICC) |
1:50-200 |
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