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Tau protein(Ser739) Polyclonal Antibody, AbBy Fluor® 680 Conjugated

Applications

  • WB
  • IF(IHC-P)
  • IF(IHC-F)
  • IF(ICC)

Reactivity

  • Rat

Predicted Reactivity

  • Human
  • Mouse
  • Dog
  • Cow
  • Rabbit
Overview
Catalog # bs-3489R-BF680
Product Name Tau protein(Ser739) Polyclonal Antibody, AbBy Fluor® 680 Conjugated
Applications WB, IF(IHC-P), IF(IHC-F), IF(ICC)
Specificity This phosphorylation site is homologous to that of Ser714 in Mouse and Ser733 in Rat.
Reactivity Rat
Predicted Reactivity Human, Mouse, Dog, Cow, Rabbit
Specifications
Conjugation AbBy Fluor® 680
Host Rabbit
Source KLH conjugated synthetic phosphopeptide derived from human Tau protein around the phosphorylation site of Ser739 [VD(p-S)PQ]
Modification Site Ser739
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID 4137
Swiss Prot P10636
Subcellular location Cytoplasm, Cell membrane
Synonyms TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103; Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau; MAPT
Background Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Application Dilution
WB 1:300-5000
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200