Overview |
bs-13641R-BF555 |
GRB 14 Polyclonal Antibody, AbBy Fluor® 555 Conjugated |
IF(IHC-P), IF(IHC-F), IF(ICC) |
This antibody may also detect the similar protein GRB10 due to an 83% sequence similarity in the immunogen sequence. |
Human |
Mouse, Rat, Dog, Cow, Sheep, Horse, Chicken, Rabbit |
Specifications |
AbBy Fluor® 555 |
Rabbit |
KLH conjugated synthetic peptide derived from human GRB 14 |
221-320/540 |
Polyclonal |
IgG |
1ug/ul |
Purified by Protein A. |
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
Target |
2888 |
Q14449 |
Cytoplasm, Cell membrane |
Growth factor receptor-bound protein 14; GRB14 adapter protein; GRB14 |
Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal. |
Application Dilution |
IF(IHC-P) |
1:50-200 |
IF(IHC-F) |
1:50-200 |
IF(ICC) |
1:50-200 |