Overview |
bs-13216R-HRP |
Frizzled 10/CD350 Polyclonal Antibody, HRP Conjugated |
WB, ELISA, IHC-P, IHC-F |
Due to the similarity of this protein to Frizzled 9, there is a chance that this antibody will react with this protein based on homology. |
Human, Mouse, Rat |
Dog, Cow, Sheep, Pig, Chicken |
Specifications |
HRP |
Rabbit |
KLH conjugated synthetic peptide derived from human Frizzled 10/CD350 |
101-200/581 |
Polyclonal |
IgG |
1ug/ul |
Purified by Protein A. |
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
Target |
11211 |
Q9ULW2 |
Cell membrane |
Fz10; FzE7; CD350; FZ-10; hFz10; Frizzled-10; FZD10 |
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. |
Application Dilution |
WB |
1:300-5000 |
ELISA |
1:500-1000 |
IHC-P |
1:200-400 |
IHC-F |
1:100-500 |