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ATG12 Polyclonal Antibody, PE Conjugated

Applications

  • WB

Reactivity

  • Mouse
  • Rat

Predicted Reactivity

  • Human
  • Dog
  • Cow
  • Pig
  • Rabbit
Overview
Catalog # bs-4012R-PE
Product Name ATG12 Polyclonal Antibody, PE Conjugated
Applications WB
Reactivity Mouse, Rat
Predicted Reactivity Human, Dog, Cow, Pig, Rabbit
Specifications
Conjugation PE
Host Rabbit
Source KLH conjugated synthetic peptide derived from human ATG12
Immunogen Range 101-187/187
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID 9140
Swiss Prot O94817
Subcellular location Cytoplasm
Synonyms APG12; FBR93; APG12L; HAPG12; Ubiquitin-like protein ATG12; Autophagy-related protein 12; APG12-like; ATG12
Background Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG1 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus.
Application Dilution
WB 1:300-5000