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Caspase-8 (C-terminal region) Antibody

Applications

  • WB

Reactivity

  • Human
Overview
Catalog # bsm-70376M
Product Name Caspase-8 (C-terminal region) Antibody
Applications WB
Specificity The antibody detects a 55 kDa* protein corresponding to the molecular weight of Caspase-8 on SDS-PAGE immunoblots of human Jurkat, K562, and A431 cells.
Reactivity Human
Specifications
Conjugation Unconjugated
Host Mouse
Source Clone (M382) was generated from a recombinant protein containing amino acid residues in the C-terminal region of human Caspase-8.
Clonality Monoclonal
Clone # M382
Isotype IgG2a
Purification Purified by Protein A.
Storage Buffer PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Storage Condition Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Target
Swiss Prot Q14790
Synonyms Caspase-8, ced3, NEDD2-like protein,p15, p10
Background The caspases are a group of cysteine enzymes, which cleave proteins in response to intrinsic and extrinsic pathways that cause apoptotic cell death. The caspases can be grouped into two subgroups based on their roles in apoptosis. Initiator caspases (caspases 2, 8, 9, and 10) are activated through the apoptosis-signaling pathways and activate the effector caspases (caspases 3, 6, and 7) which carry out apoptosis. Caspase cascades are initiated through assembly of multiprotein complexes that trigger activation of the initiator caspases, which are then released and are able to activate the downstream effector caspases.
Application Dilution
WB 1:300-5000