| Overview |
| bsm-70037M |
| Calcitonin Gene Related Peptide (CGRP) Antibody |
| ICC |
| Specific for Calcitonin Gene Related Peptide. Also recognizes rat beta-CGRP and human alpha-CGRP (10-fold less sensitivity compared to rat alpha-CGRP). Suggested positive controls are dorsal root ganglia, pancreas and gut. |
| Human, Rat |
| Specifications |
| Unconjugated |
| Mouse |
| Purified rat alpha-CGRP. |
| Monoclonal |
| 4901 |
| IgG2a |
| Lot Dependent |
| Purified by Protein G. |
| 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. |
| Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. |
| Target |
| 24241 |
| P01256 |
| Calcitonin/calcitonin related polypeptide alpha antibody, Alpha type CGRP antibody, Beta type CGRP antibody, CALC1 antibody, CALC2 antibody, CALCA antibody, CALCB antibody, Calcitonin 1 antibody, Calcitonin 2 antibody, Calcitonin gene related peptide I antibody, Calcitonin gene related peptide II antibody, Calcitonin related polypeptide alpha antibody, Calcitonin related polypeptide beta antibody, CGRP antibody, CGRP I antibody, CGRP II antibody, CGRP1 antibody, CGRP2 antibody, CT antibody, Katacalcin antibody, KC antibody |
| Calcitonin Gene Related Peptide [CGRP] is a 37 amino acid peptide and is the most potent endogenous vasodilator currently known (Brain et al.,1985). CGRP is primarily produced in nervous tissue, however, its receptors are expressed throughout the body. CGRP is also strongly implicated in the vasodilatory effect of endogenous cannabinoid anandamide in the brain. This effect was found to be antagonized by capsazepine. CGRP is also currently a major target of research in regards to factors effecting the onset of migraine headaches (Edvinsson L., 2003). CGRP antibodies have been used successfully in immunoneutralization (Wong et al., 1993). |
| Application Dilution |
| ICC |
1:100-500 |
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