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human IL-17A/PE

Applications

  • FCM

Reactivity

  • Human
Overview
Catalog # bsm-30146M-PE
Product Name human IL-17A/PE
Applications FCM
Reactivity Human
Specifications
Conjugation Unconjugated
Host Mouse
Clonality Monoclonal
Clone # 5H3
Isotype IgG1/Kappa
Concentration n/a
Purification Affinity purified by Protein G
Storage Buffer 0.01M PBS, 0.5%BSA, 0.03% Proclin300
Storage Condition Store at 2-8℃. Protect from light. Avoid freezing.
Target
Gene ID 3605
Swiss Prot Q16552
Synonyms Interleukin-17A; CTLA-8; CTLA 8; CTLA8; Cytotoxic T lymphocyte associated antigen 8; Cytotoxic T lymphocyte associated serine esterase 8; IL 17A; IL-17A; IL-17; Interleukin 17; Interleukin-17; Interleukin 17A; Interleukin17; Interleukin17A; IL17_HUMAN.
Background This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A. [provided by RefSeq, Sep 2020]
Application Dilution
FCM 1:20-100