POP1 Polyclonal Antibody
Applications
Reactivity
Overview | |
Catalog # | bs-9107R |
Product Name | POP1 Polyclonal Antibody |
Applications | WB, IHC-P, IF(IHC-P) |
Reactivity | Human, Mouse, Rat |
Specifications | |
Conjugation | Unconjugated |
Host | Rabbit |
Source | KLH conjugated synthetic peptide derived from human ASC2/POP1 |
Immunogen Range | 11-70/89 |
Clonality | Polyclonal |
Isotype | IgG |
Concentration | 1ug/ul |
Purification | Purified by Protein A. |
Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
Storage Condition | Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
Target | |
Gene ID | 10940 |
Synonyms | PAAD domain only protein; POP1; PYDC1; Pyrin domain containing 1; Pyrin only protein 1; PYDC1_HUMAN. |
Background | The death domain (DD) superfamily of proteins share one or more of the following domains: the DD, DED (death-effector domain), CARD (caspase-recruitment domain) and PYD (Pyrin domain). Each of these domains is characterized by a canonical death domain fold, which consists of a bundle of five or six antiparallel -helices. As their names suggest, these domains play prominent roles in programmed cell death. ASC2 (apoptosis-associated speck-like protein containing a CARD 2), also known as Pyrin-only protein 1 or PADD-only protein 1, is an 89 amino acid member of the DD superfamily that contains one Pyrin domain. Localized to the cytoplasm, ASC2 interacts with ASC to modulate NF-B and pro-caspase-1 regulation. ASC2 is predominantly expressed in monocytes, macrophages and granulocytes. |
Application Dilution | |
WB | 1:300-5000 |
IHC-P | 1:200-400 |
IF(IHC-P) | 1:50-200 |