Fbx15 Polyclonal Antibody, Biotin Conjugated
Applications
Reactivity
Predicted Reactivity
Overview | |
Catalog # | bs-8396R-Biotin |
Product Name | Fbx15 Polyclonal Antibody, Biotin Conjugated |
Applications | WB, ELISA, IHC-P, IHC-F |
Reactivity | Mouse, Rat |
Predicted Reactivity | Human, Pig |
Specifications | |
Conjugation | Biotin |
Host | Rabbit |
Source | KLH conjugated synthetic peptide derived from human Fbx15 |
Immunogen Range | 101-200/510 |
Clonality | Polyclonal |
Isotype | IgG |
Concentration | 1ug/ul |
Purification | Purified by Protein A. |
Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
Storage Condition | Store at -20°C for 12 months. |
Target | |
Gene ID | 201456 |
Subcellular location | Cytoplasm |
Synonyms | F box protein 15; F-box only protein 15; F-box protein 15; Fbxo15; MGC39671; FBX15_HUMAN. |
Background | FBXO15, also known as FBX15, is a 434 amino acid protein that contains one C-terminal F-box domain and belongs to the F-box family of proteins. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune response, signaling cascades and developmental processes) through the targeting of proteins, such as cyclins, cyclin-dependent kinase inhibitors, IkB-a and b-catenin, for degradation by the proteasome after ubiquitination. Via its F-box domain, FBXO15 can directly interact with Skp1 p19 and CUL-1. In addition, FBXO15 is a target of the transcription factor Oct-3/4, however, it does not appear to be essential for early development and fertility. |
Application Dilution | |
WB | 1:300-5000 |
ELISA | 1:500-1000 |
IHC-P | 1:200-400 |
IHC-F | 1:100-500 |