Overview |
bs-8346R-Biotin |
FGFR1OP2 Polyclonal Antibody, Biotin Conjugated |
WB, ELISA, IHC-P, IHC-F |
Human, Mouse, Rat, Dog, Horse, Rabbit |
Specifications |
Biotin |
Rabbit |
KLH conjugated synthetic peptide derived from human FGFR1OP2 |
51-150/253 |
Polyclonal |
IgG |
1ug/ul |
Purified by Protein A. |
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
Store at -20°C for 12 months. |
Target |
26127 |
Cytoplasm |
DKFZp564O1863; FGFR1 oncogene partner 2; HSPC123; HSPC123 like; FGOP2_HUMAN. |
FGFR1OP2 belongs to the SIKE family. The FGFR1OP2 (FGFR1 oncogene partner 2) gene was identified through its involvement in a fusion with the FGFR1 gene. FGFR1OP2 may be involved in the wound healing pathway. It is expressed in bone marrow, spleen and thymus. A chromosomal aberration involving FGFR1OP2 may be a cause of stem cell myeloproliferative disorder (MPD). Insertion ins(12;8)(p11;p11p22) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T cell or B cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein FGFR1OP2-FGFR1 may exhibit constitutive kinase activity and be responsible for the transforming activity. |
Application Dilution |
WB |
1:300-5000 |
ELISA |
1:500-1000 |
IHC-P |
1:200-400 |
IHC-F |
1:100-500 |